What's OLETF Rat?

    Otsuka Long Evans Tokushima Fatty (OLETF) rat is a useful animal model of type II diabetes with obesity. It was developed by Kawano et al. (1991, 1992) and has been maintained in the Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd. Our company has been providing the OLETF rat as useful resources for diabetes study. Please contact us if you would like to use this strain for your research project.

It shows a clinically relevant phenotypes of diabetes such as

• hyperinsulinemia
• hyperglycemia
• insulin resistance
• hypertriglycemia
• mild obesity

It shows a sex-dependent manner in terms of diabetes ncidence.

• 100% penetrance of diabetes in male OLETF rats of 25 weeks

In light of genetics

• polygenically-controlled diabetes
• some critical genetic components revealed by extensive QTL analysis.

For more comprehensive information and genetic data of this strain, please refer to our publications (see references in homepage) and QTL databases in this site.

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